January 2008

New bases for DoM
January 1, 2008

Direct ortho-Cupration: A New Route to Regioselectively Functionalized Aromatics When talking about directed ortho-metallation (DoM), most people think about organolithium bases,…

Read More
Triazoles through ruthenium
January 1, 2008

Ruthenium-Catalyzed Cycloaddition of Aryl Azides and Alkynes The use of a Ru catalyst allows now the preparation of 1,5-disubstituted triazoles under…

Read More
Halogenating the gap
January 1, 2008

Meta-Halogenation of 1,3-Disubstituted Arenes via Iridium-Catalyzed Arene Borylation Preparation of aryl halides is a key step in many syntheses, but the…

Read More
Nitrile synthesis by tandem cyanation/alkylation
January 1, 2008

Convergent Synthesis of Polysubstituted Aromatic Nitriles via Palladium-Catalyzed C–H Functionalization Metal-mediated alkylations and cyanations are not new but, what about accomplishing…

Read More
R&D Work: Microwave-assisted aza-Cope rearrangement
January 1, 2008

Microwaves are one of the most useful tools for medicinal chemists. Reactions that typically required hours can now be carried out…

Read More
Editorial
January 1, 2008

This is the first issue of our newsletter. Yes, another one. There are other newsletters centered in industry drivers, news, product…

Read More
Boric acid-catalyzed amidation
January 1, 2008

Maybe it is time to forget time-consuming and tedious protocols for amide formation. This boric acid-catalyzed amidation method seems promising. The…

Read More
Contract Research
January 1, 2008

We are involved in several Drug Discovery projects for pharmaceutical and biotech companies, working with them side by side in order…

Read More
Review of the month: Pd(II) reactions
January 1, 2008

Everybody knows that Pd(0) is widely used for the formation of C–C, C–O and C–N bonds. However, the use of palladium(II)…

Read More
Welcome to GalChimia Letters!
January 1, 2008

Welcome to our newsletter, Doing Chemistry. Since this is the first issue, we believe necessary to establish the “broad and scope”…

Read More