January 2008

New bases for DoM
January 1, 2008 · Papers & Reviews

Direct ortho-Cupration: A New Route to Regioselectively Functionalized Aromatics When talking about directed ortho-metallation (DoM), most people think about organolithium bases,…

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Triazoles through ruthenium
January 1, 2008 · Papers & Reviews

Ruthenium-Catalyzed Cycloaddition of Aryl Azides and Alkynes The use of a Ru catalyst allows now the preparation of 1,5-disubstituted triazoles under…

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Halogenating the gap
January 1, 2008 · Papers & Reviews

Meta-Halogenation of 1,3-Disubstituted Arenes via Iridium-Catalyzed Arene Borylation Preparation of aryl halides is a key step in many syntheses, but the…

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Nitrile synthesis by tandem cyanation/alkylation
January 1, 2008 · Papers & Reviews

Convergent Synthesis of Polysubstituted Aromatic Nitriles via Palladium-Catalyzed C–H Functionalization Metal-mediated alkylations and cyanations are not new but, what about accomplishing…

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R&D Work: Microwave-assisted aza-Cope rearrangement
January 1, 2008 · Made in GalChimia

Microwaves are one of the most useful tools for medicinal chemists. Reactions that typically required hours can now be carried out…

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Editorial
January 1, 2008 · Editorial

This is the first issue of our newsletter. Yes, another one. There are other newsletters centered in industry drivers, news, product…

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Boric acid-catalyzed amidation
January 1, 2008 · Papers & Reviews

Maybe it is time to forget time-consuming and tedious protocols for amide formation. This boric acid-catalyzed amidation method seems promising. The…

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Contract Research
January 1, 2008 · Made in GalChimia

We are involved in several Drug Discovery projects for pharmaceutical and biotech companies, working with them side by side in order…

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Review of the month: Pd(II) reactions
January 1, 2008 · Top Reviews

Everybody knows that Pd(0) is widely used for the formation of C–C, C–O and C–N bonds. However, the use of palladium(II)…

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Welcome to GalChimia Letters!
January 1, 2008 · Editorial

Welcome to our newsletter, Doing Chemistry. Since this is the first issue, we believe necessary to establish the “broad and scope”…

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