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Agatha Christie’s Tribute
January 1, 2011
· New Papers

Cyanation of Aryl Halides Mild cyanation methods. The preparation of aryl cyanides is one of those reactions that med chemists do…

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Even easier
January 1, 2011
· New Papers

Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)6 or W(CO)6 Preparation of Weinreb amides from…

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Counterintuitive
January 1, 2011
· New Papers

A Practical, One-Pot Synthesis of Sulfonylated Pyridines Sulfonylation of pyridine rings. Some time ago I had a very interesting talk with…

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Incredible but True
January 1, 2011
· New Papers

Transition-Metal-Free O-, S-, and N-Arylation of Alcohols, Thiols, Amides, Amines, and Related Heterocycles Introduction of nucleophiles using superbase. Looks like an…

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Have You Seen an Oxygen?
January 1, 2011
· New Papers

Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Alkyl Ethers: Enantioselective Synthesis of Diarylethanes Ni-catalyzed replacement of methoxy groups. I must admit that when…

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Review of the month : Bioisosteres in Drug Design
January 1, 2011
· Top Reviews

Bioisosteres are the daily bread for medicinal chemists, though isosterism is in fact an old concept. The title of this review…

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Right by Design
January 1, 2011
· Made in GalChimia

Design of Experiments (DOE) is a powerful tool commonly used by process chemists in the scale up and process development stages….

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