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Bulky Amines that Work
February 27, 2015
· New Papers

Rational Ligand Design for the Arylation of Hindered Primary Amines Guided by Reaction Progress Kinetic Analysis A working protocol for the…

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A New Age for Chlorination
February 20, 2015
· New Papers

A Practical Lewis Base Catalyzed Electrophilic Chlorination of Arenes and Heterocycles Mild chlorination method of arenes and heteroarenes. Here you have…

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R&D Work: One-pot Synthesis of Pyrazoles using Flow Chemistry
February 19, 2015
· Made in GalChimia

Preparation of Pyrazoles from Acetophenones in Flow using a 2–Stage Reaction Flow Chemistry is becoming more and more popular. We have…

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stem_cell_01
Who had come in first ?
February 19, 2015
· Editorial

Being French, living in Spain and working in English I read different news items from different countries in several languages. Recently,…

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Earth-Abundant Catalyst
February 18, 2015
· New Papers

Silylation of C–H bonds in aromatic heterocycles by an Earth-abundant metal catalyst C-H activation using a catalyst that is not based…

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fluorination_wizard
Review of the month: Fluorination Methods
February 16, 2015
· Top Reviews

It is curious how these things happen. These last weeks I have been checking old entries of the blog, and I…

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Superposed Binding Pose
Beware the Binding Pose
February 12, 2015
· Editorial

One of my favourites blogs, which I have mentioned in previous posts, is In the Pipeline, written by Derek Lowe. He…

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Not a Poison Anymore?
February 10, 2015
· New Papers

Synthesis of diaryl thioethers from aryl halides and potassium thiocyanate A method for the preparation of thioethers using a Palladium catalyst…

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The Final Step
February 9, 2015
· New Papers

Metal-Catalyzed Azidation of Tertiary C–H Bonds Suitable for Late-Stage Functionalization Another entry in the wonderful world of the C-H activation, this…

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Case Study: Custom Synthesis
February 9, 2015
· Made in GalChimia

In 2014 we were approached to prepare an intermediate in bulk. Our customer had specific issues finding suppliers for this product….

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