Papers & Reviews

Glioblastoma
Good for your brain and your lab
June 12, 2020

Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…

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fluorine pros and cons
Fluorine, pros and cons
May 27, 2020

The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?

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Three tough atoms
Three tough atoms
February 14, 2020

Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.

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Difluoromethylation of benzylic positions with copper catalysis
Another long distance call
January 13, 2020

Introduction of a CF2H moiety in benzylic positions using a copper catalyst.

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The Less Smelly Way
December 2, 2019

This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Copper nuggets
Long distance call
November 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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Mitsunobu reaction
Catalytic Mitsunobu: The face-lift of a workhorse
October 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

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Flowing into indoles
Flowing into indoles
September 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

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Macrocycles
Review of the Month: Opportunities with Macrocycles
June 26, 2019

The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.

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Birch reduction
Re-energizing the Birch reduction
May 9, 2019

Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.

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