New papers

Microfluidic Chip
Lighting up the flow
julio 9, 2020

Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.

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Glioblastoma
Good for your brain and your lab
junio 12, 2020

Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…

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fluorine pros and cons
Fluorine, pros and cons
mayo 28, 2020

The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?

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Three tough atoms
Three tough atoms
febrero 14, 2020

Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.

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Another long distance call
enero 13, 2020

Introduction of a CF2H moiety in benzylic positions using a copper catalyst.

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The Less Smelly Way
diciembre 2, 2019

This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Copper nuggets
Long distance call
noviembre 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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mitsunobo reaction
Catalytic Mitsunobu: The face-lift of a workhorse
octubre 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

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Flowing into indoles
Flowing into indoles
septiembre 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

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Macrocycles
Review of the Month: Opportunities with Macrocycles
junio 26, 2019

The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.

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