| Top Five |
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| Boric Acid Catalyzed Amidation |
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| Maybe it is time to forget time-consuming and tedious methods for amide formation. This boric acid catalyzed amidation method seems promising. |
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| More info |
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| Nitrile synthesis by tandem cyanation/alkylation |
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| Metal-mediated alkylations and cyanations are not new but, what about accomplishing both in the same step? A group in Canada shows how to prepare ortho alkyl and aryl nitriles in a one-pot reaction. |
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| More info |
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| Halogenating the gap |
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| Preparation of aryl halides is a key step in many syntheses. But the introduction of an halogen in meta to other substituents is not usually trivial. The key to that reaction is an Iridium catalyst. |
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| More info |
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| Triazoles through Ruthenium |
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| The use of a Ru catalyst allows now the preparation of 1,5-disubstituted triazoles under microwave irradiation. Another useful tool for the medicinal chemists. |
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| More info |
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| New bases for DoM |
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| When talking about Directed ortho Metallations (DoM) most people think about organolithium bases. But the use of Lipshutz-type amidocuprates can change that. |
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| More info |
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| Editorial |
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This is the first issue of our newsletter. Yes, another one. There are other newsletters centered in industry drivers, news, product updates and others, so the unavoidable question is 'Why another newsletter'?
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| R&D Work : Microwave assisted aza-Cope rearrangement |
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| Microwaves are one of the most useful tools for the medicinal chemist. Reactions which needed hours can now be carried out in minutes using a microwave reactor. We have developed a new method for the microwave assisted aza-Cope rearrangement of N-allylanilines. |
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| Read more... |
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| Review of the month : Pd(II) reactions |
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| Everybody knows that Pd(0) is widely used for the formation of C-C, C-O and C-N bonds. However, the use of Palladium(II) is less known, even though many Pd(II)-complex-catalyzed reactions starting from not functionalized, cheap substrates are available. Therefore, we have selected as review of this month "C-C, C-O, C-N Bond Formation on sp2 Carbon by Pd(II)-Catalyzed Reactions Involving Oxidant Agents" by Beccalli et al (Chem. Rev. 2007; 107(11) pp 5318 - 5365). This review covers the full range of Pd(II) couplings and will serve as reminder that very interesting and useful transformations, specially those involving heterocyclic systems, are possible using the humble and faithful Pd(OAc)2. |
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| Our services : Contract Research |
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| We are involved in several Drug Discovery projects for pharmaceutical and biotech companies, working with them side by side in order to prepare new compounds for the screening cascade. We contribute with innovation, productivity, communication and flexibility: the aim is prepare the maximum number of different compounds in the least possible time. If you have needs of a reliable, cost-effective and high quality contract research service contact with us.
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