| Top Five |
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| A step forward |
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| If this method can be further expanded, the days of phosphorus oxychloride are numbered. Keep reading. |
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| More info |
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| The shortest way |
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| Sometimes the fastest way is the shortest way. Now, also true for arylamines. |
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| More info |
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| Copper, one way or the other |
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| In previous issues of this newsletter we have talked about direct C-H functionalization of indoles. Copper can make a difference. |
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| More info |
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| We are on offer |
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| Carbonylation has changed a lot from that pioneering reactions at high pressure and is becoming an everyday reaction. |
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| More info |
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| Palladium 1, Friedel-Crafts 0 |
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| Preparation of aryl ketones is becoming easier with the new palladium-mediated coupling protocols. |
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| More info |
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| Racemic resolution |
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There are a number of chiral myths around related with pharmaceutical products. Though nobody here neglects the importance of enantioselective synthesis, sometimes there is no a real need of such advanced methods. Moreover, sometimes the old fashioned racemic resolution of a chiral compound is not only a good option, but an essential step in the development of a New Chemical Entity. We present here an example of a project facing up the challenge of the racemic resolution of a promising candidate.
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| Review of the month : Coinage metals |
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| Coinage metals is probably an intriguing title for most of us. What does that mean? To put it briefly, it refers to those metals used to manufacture coins. Once you think about it a minute, probably those metals are copper, silver and gold. Today we use other metals for coins, but since the ancient times this triad has been used to make the filthy lucre. Or not so filthy, because once you enter into the realm of the organic chemistry, the role of these metals is everything but filthy. Though the synthetic applications of gold are still expanding, those of silver and especially copper are wide and constitute the core of many modern organometallic reactions. So we have selected for this month the full issue "COINAGE METALS IN ORGANIC SYNTHESIS", edited by Bruce H. Lipshutz and Yoshinori Yamamoto (Chem. Rev. 2008, 108(8)). The issue includes reviews covering the applications of Copper, Silver and Gold in many different subjects. |
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| Read more... |
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| Our services : Custom Synthesis |
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| Do you require a compound that is not commercially available? An impurity needed in your cGMP process? Are you looking for a small quantity of a standard used in pharmacological screening? In GalChimia we prepare these and other compounds at the request of our clients, all under the strictest confidentiality.
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