| Special Double Issue |
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| You have on your screen a special double issue of our newsletter. The reasons for this are summarized in just one word: time. We are involved in a number of exciting changes for the near future and the lack of time, one of the main problems of the civilized world, finally made impossible to get this issue on time. So we have made virtue of necessity and put all the material of the issues 10 and 11 into a special double issue. As and old movie stated, "Big is back, because bigger is better than ever!". So enjoy. |
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| Reaction Optimization for Medicinal Chemists |
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| Reaction optimization sounds familiar to many medicinal chemists, but is one of those things than usually can't be done. The medicinal chemistry work is based on preparing new products, with scarce time to optimize anything until a good candidate is generated. However, sometimes optimizing a basic reaction of the route it's worth it. |
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| Read more... |
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| A Bunch of Good Reviews |
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| We have selected four reviews covering as many topics in organic synthesis. The review by van Otterlo and de Koning examines the use of the Ring-closing metathesis (RCM) reaction in the synthesis of aromatic compounds. This can sound almost alien to medicinal chemists, used to take the aromatic building blocks and scaffolds as they come, but it can be an interesting method for the preparation of very specific substitution patterns. |
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| Read more on RCM... |
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| The second review, by Afonso et al., covers new greener methods for the preparation of heterocycles, including ionic liquids, supercritical CO2, solvent free reactions, aqueous media and others. Some of these methods are probably exotic, but it is a good review about possible synthetic venues in a near future. |
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| Read more on heterocycles... |
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| The next work, by Swamy et al., is centered on new developments and conditions of the Mitsunobu reaction, and all-time classic. This extensive review includes information on many exciting novelties. |
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| Read more on Mitsunobu... |
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| Finally, the review by Bellina and Rossi, the one with the longest title of our selection, is focused on the coupling of aromatic compounds with activated sp3-hybridized C-H bonds, a field which is attracting more and more attention in the last years. |
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| Read more on couplings... |
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| Our services : Reaction optimization |
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| Design of Experiments (DoE) sounds familiar to all process chemists. In GalChimia we apply DoE principles to the everyday work in order to tune important reactions of your process. Additionally, we have also improved and optimized pivotal reactions used in drug discovery projects, so the chemists can use their time in the critical process of preparing new compounds. If you have a reaction which needs to be improved, ask us.
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