Newsletter Issue 11 Oct-Nov 2009

Top Five The World Turned Upside Down A method for the introduction of a nitro group by palladium catalysis.    More info Weinreb's Way A new reagent for the formation of Weinreb's amides from carboxylic acids in one step.    More info The Gap Between the Rings, 2nd part A method for the palladium-catalyzed benzylation of heterocycles.    More info Twisted Isoxazoles A new one-pot procedure for the synthesis of isoxazoles with reverted regiochemistry.    More info Iron Plus Water = Stain? Interesting protocol for the iron catalyzed coupling of pyrazoles in aqueous medium.    More info	Some Thoughts About Methodology In the next months we will publish a couple of papers on our research about organometallic couplings. Even if they are not accepted, these papers are clearly in the field of methodology, as opposed to those papers aimed to the synthesis of a single target. There are clear differences between both types of papers and this time we would like to share with you our views on those works developing new methodology.    Read more...  Review of the month : Libraries survey Some things take their time. In this case, the thing is an extensive survey of the medicinal chemistry libraries published in 2008, classified by targets, categories and others. The review includes tables with polymer-supported reagents, scavengers and linkers in the fluorous and non-flourous categories. The "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2008", by Dolle et al. is specially recommend for medicinal chemists.    Read more...  Our services : New Products on Catalog In the previous issue we have presented a paper on the functionalization of arylboronic acids using 2-(1H-Pyrazol-5-yl)aniline as directing group. This compound was not commercially available and had to be prepared. In order to save time to our medicinal chemists, we have included this compound in our catalog. See other novelties and offers for other products in catalog.    Read more...
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