Newsletter
Issue 12
Jan-Feb 2010
 Top Five
Shake Well Before Use
Easy and wet protocol for the Negishi reaction.
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Greenhouse Effect
A carbonylation reaction which uses CO2.
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Umpolung
An inverted alternative to the usual Buchwald-Hartwig amination.
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Bone Dry
Selective method for the anhydrous hydrolysis of nitriles.
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On Phenols
Four papers using phenols as starting materials for organometallics couplings.
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 Interesting times
An ancient chinese curse says that "May you live in interesting times". This crisis is an interesting time indeed, but you can extract some lessons for this hard time. One of this lessons was suggested to me by a commercial on TV.
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 Review of the month : Coupling of Heteroarene C-H bonds
In several issues of this newsletter we have included several papers on the topic of the C-H direct functionalization. There has been an increasing interest in this field and the number of papers published grows each month. Bellina and Rossi have just published a review covering the recent advances in the functionalization of heteroarene C-H bonds with aryl halides, pseudohalides, trifluoroborates and iodonium salts. A quick way for medicinal chemists to keep in touch with this topic.
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 Our services : HPLC Services
GalChimia is known by his services in the field of Synthetic Organic Chemistry, but that work relies also on an efficient, well equiped analytical department supporting the chemists in the lab. We extend that support to our clients providing them with a broad array of HPLC techniques, including chiral and preparative LC. See here more information about our capabilities on analytical and preparative HPLC.
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