| Top Five |
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| Reduzing... |
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| A mild, selective reduction of tertiary amides catalyzed by zinc acetate. |
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| More info |
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| A New Way to Weinreb |
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| A method for the preparation of Weinreb amides by palladium-catalyzed cross-coupling. |
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| More info |
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| Nicholas Nickleby |
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| Introduction of alkyl chains into aromatic rings catalyzed by Nickel. |
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| More info |
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| More C-H Activation |
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| Synthesis of fused pyrazoles by coupling with an activated C-H. |
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| More info |
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| Copperhead |
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| Alkylation of poor nucleophilic amines and sulfonamides with alcohols using a copper catalyst. |
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| More info |
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| New Website |
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| We are proud to announce the launching of our new website. The site has been completely built up with a brand new image, offering more info about who we are and what we do. Our new image campaign has been very successful, attracting many positive comments from our clients, collaborators and occasional visitors. Take a look at the new WWW.GALCHIMIA.COM!
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| R&D Work : Alkylation of Amines with Alkylboronic Acids |
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| In 2009 we published our results on the selective monomethylation of anilines and other heterocyclic amines through a copper-promoted cross-coupling with methylboronic acid. We would like to present now an expansion of the work that allows the selective introduction of many different alkyl groups into aromatic amines, a method that many medicinal chemists will welcome as a very useful addition to their toolkit.
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| Read more... |
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| Review of the month : Meldrum's Acid |
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| Meldrum's Acid is the trivial name of the 2,2-dimethyl-1,3-dioxane-4,6-dione; this amazingly simple, symmetric molecule is a very interesting starting material for many different molecules, from b-ketoacids to natural products. In this review by Aaron M. Dumas and Eric Fillion they cover recent advances in the chemistry of this scaffold. |
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| Our services : Stability Studies |
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| Many of our clients come to us looking for new compounds intended to be used in preliminary in vivo assays. The compounds must be administered to the selected animals in a controlled way, and sometimes a very simple but critical question arises: Are these compounds stable? We help our clients answer this question in order to increase the success of the assay.
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