| Special Double Issue |
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| You have on your screen a new special double issue of our newsletter. Once again the reason is lack of time. By mid-year some of the changes and opportunities for the near future take shape, requering any additional effort you can provide. But once again we have put all the material of these four months into a special double issue. We are back ! |
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| Flow Chemistry is the Last Trend |
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| When you spend some time working in the field of Organic Synthesis you understand that Chemistry, as many other things, it is a matter of fashion. So far I have seen Solid Phase Organic Synthesis (SPOS), Combinatorial Chemistry, Catalytic Antibodies and others. Each trend has the corresponding group of advocates and critics, all moving around the fantastic benefits and results you could get from the new technology. So what else is new? Well, this time it is Flow Chemistry. |
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| Read more... |
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| Good Reviews on Flow Chemistry |
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| We have selected some sources covering the topic of this issue. First we have selected a special issue from the Organic Process Research & Development. It is focused on continuous processes and its impact in the fine chemicals and the pharmaceutical industry. Maybe OPRD is not the usual journal for medicinal chemists, but it is worth reading these articles. |
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| Read more on Continuous Processes... |
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| The second review, by Steven Ley et al., is a nice introduction into several aspects of flow chemistry, including hardware, supplier and typical reactions that can be done with these systems. Steven Ley is one of the more prominent figures of both supported reagents and flow chemistry. |
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| Read more on Emerging Technologies... |
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| The next work is a SAFC document focused on how the use of flow chemistry can deliver quickly optimized manufacturing processes. It touches briefly on very basic but critical concepts. |
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| Read more on SAFC... |
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| Finally, we recommend a couple of sites from vendors selling flow chemistry equipment. Chemtrix has developed the Labtrix and Plantrix reactors, intended for development of conditions and production respectively, while Uniqsis offers the FlowSyn, an equipment intended for preparative work. In the sites of these two companies you will find papers, technical explanations, application notes and much more. Application notes are specially interesting to see cases where real life chemistry problems have been successfully solved using flow chemistry. |
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| Read more on Applications by Chemtrix and Uniqsis |
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| Our services : Reaction Optimisation |
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| Design of Experiments (DoE) sounds familiar to all process chemists. In GalChimia we apply DoE principles to both process development and drug discovery projects in order to improve critical reactions. See in our website some study cases showing our skills in this area. If you have a reaction that needs to be improved, ask us.
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