| The End of the World |
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| Probably most of you are not familiar with this song by R.E.M., dated on 1987. Twenty years after that, the title has become true. You are probably thinking right now 'Oh, no, another guy talking about the crisis!'. And you are right! But the crisis I am talking about is not the financial crisis; it is the big pharma crisis. This one has been coming much earlier than Lehman Brothers crack, and, as usual, many people saw it coming.
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 Read more... |
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| A Bunch of Good Reviews |
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| How can we say? There were so many interesting reviews in August that simply we could not make our mind. So let's read them all. The first by Menéndez et al. covers the advances in chemistry of tetrahydroquinolines. |
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| Read more on tetrahydroquinolines... |
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| The second review, by Fustero and Simón-Fuentes, covers the even more interesting pyrazoles, and includes not only synthesis but also functionalization. |
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| Read more on pyrazoles... |
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| The third review, by Hirata and Narumiya, is about the prostanoid receptors. The efforts to obtain agonists and antagonists for these receptors have also been reviewed recently, but any new review is welcomed. |
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| Read more on prostanoid receptors... |
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| In the fourth review, Marson talks about the H4 receptor, the youngest member of the Histamine receptors family discovered ten years ago. |
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| Read more on H4 receptor... |
| | Finally, the review by Barreiro et al. is a nice work on a top-rated subject in medicinal chemistry, methylation and its effects. Read everything about the magic methyl effect! |
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| Read more on methylation... |
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| Apologies and changes |
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| Well, it has been a long, long time. Issue 18 of the newsletter was published on April 1st, so you readers are probably wondering what happened. Once again the reason is lack of time, what else? We have been in the middle of a turmoil in the second quarter, stablishing new collaborations, studying projects and arranging many details for the near future. And as usual, one of the first casualties has been the newsletter. We are very sorry, and we are trying to solve the problem. Keep on reading! |
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| Read more... |
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| Top Ten |
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| OH! F? |
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| Direct conversion phenols into fluorides with a new fluorination reagent. |
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| More info |
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| CN Without CN |
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| Cyanation of protected, C-2 substituted indoles, without using a cyanide source, only DMF. |
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| More info |
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| You See It, You Don't |
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| C-H activation of phenols using a silanol directing group. |
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| More info |
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| And Now, the Other Way |
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| Copper catalyzed hydroxylation of chloro-, bromo- and iodoarenes. |
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| More info |
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| Saving Steps |
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| An aminocarbonylation protocol to introduce directly amides. |
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| More info |
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| Go, Baby, Go! |
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| Nitroalkanes and styrenes as raw materials for the preparation of diketones. |
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| More info |
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| PEG-ammonia |
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| Environmentally benign protocol for the direct amination of bromo- and iodoarenes using a Cu catalyst. |
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| More info |
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| Unusual RCM |
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| Synthesis of highly substituted indoles using a RCM approach. |
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| More info |
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| Look, no Benzyl! |
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| A C-H activation protocol used for the benzylation of imidazoles using an Iron catalyst. |
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| More info |
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| Just a little, please |
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| Catalytic protocols for the deprotection of silyl ethers using TBAF or CsF as fluoride sources. |
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| More info |
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