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Magic methyl nowadays
April 9, 2021This review from ChemSocRev by Dixon, Leight et al. covers the different methods currently available for the methylation of sp2 and sp3 C-H positions.
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Autocatalytic photoredox Chan–Lam
March 16, 2021This paper by Kozlowski and Jia uses a modern approach: a copper-catalyzed photoredox dehydrogenative Chan–Lam reaction
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One-pot access to primary sulfonamides
February 10, 2021The sulfonamide group is one of those chemical moieties that have been around for a long time, but their preparation is not always trivial.
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Easy Access to 2-Aminopyridines
December 4, 2020This paper describes the development of a novel reagent for the selective amination of pyridines at the C2 position, a work by Fier et al.
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A Different Approach to Anilines
November 24, 2020Earlier this year, Leonori et al. reported a novel and ingenious approach for the synthesis of anilines. Click here to read the full article!
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One Way or Another
October 29, 2020Today we talk about this work by Cavallo and Rueping, which describes the regioselective cleavage of epoxides and oxetanes.
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The Options Out There
October 5, 2020We feature an article from ACS Med Chem Lett. where seven different C(sp2)–C(sp3) cross-coupling methodologies are compared for highly functionalized substrates.
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Standing on the Shoulders of Giants
August 5, 2020Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.
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Julia in July
July 29, 2020Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.
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Lighting up the flow
July 9, 2020Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.
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