Three tough atoms
February 14, 2020Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.
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Another long distance call
January 13, 2020Introduction of a CF2H moiety in benzylic positions using a copper catalyst.
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The Less Smelly Way
December 2, 2019This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!
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Long distance call
November 6, 2019In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.
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Catalytic Mitsunobu: The face-lift of a workhorse
October 21, 2019This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.
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Flowing into indoles
September 5, 2019An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.
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Review of the Month: Opportunities with Macrocycles
June 26, 2019The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.
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Re-energizing the Birch reduction
May 9, 2019Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.
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Activated
May 25, 2016A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…
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Printing Your Catalyst
May 6, 20163D printing of a heterogeneous copper-based catalyst The impact of some technologies like 3D printing is remarkable. In this case, it…
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