Papers & Reviews

Standing on the shoulders of giants
Standing on the shoulders of giants
August 5, 2020

Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.

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Julia in July
Julia in July
July 29, 2020

Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.

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Microfluidic Chip
Lighting up the flow
July 9, 2020

Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.

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Glioblastoma
Good for your brain and your lab
June 12, 2020

Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…

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fluorine pros and cons
Fluorine, pros and cons
May 27, 2020

The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?

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Three tough atoms
Three tough atoms
February 14, 2020

Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.

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Difluoromethylation of benzylic positions with copper catalysis
Another long distance call
January 13, 2020

Introduction of a CF2H moiety in benzylic positions using a copper catalyst.

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The Less Smelly Way
December 2, 2019

This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Copper nuggets
Long distance call
November 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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Mitsunobu reaction
Catalytic Mitsunobu: The face-lift of a workhorse
October 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

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