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Flowing into indoles
September 5, 2019An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.
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Review of the Month: Opportunities with Macrocycles
June 26, 2019The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.
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Re-energizing the Birch reduction
May 9, 2019Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.
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Activated
May 25, 2016A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…
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Printing Your Catalyst
May 6, 20163D printing of a heterogeneous copper-based catalyst The impact of some technologies like 3D printing is remarkable. In this case, it…
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(Un)touchable
January 25, 2016Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C–F Bond Functionalizations Using a mixed catalytic system to promote the transformation of aromatic fluorides…
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More Drugs, Please
January 21, 2016One size does not fit all: Challenging some dogmas and taboos in drug discovery This brief review by Chai (Singapore) and…
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PyFluor – OH Replacement Service
October 30, 2015PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent A new reagent for the replacement of aliphatic hydroxy groups by fluorine. In…
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Multimetals for Biaryls
October 23, 2015Multimetallic catalysed cross-coupling of aryl bromides with aryl triflates A catalytic system using two metals allows the synthesis of biaryl products…
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Finally!
October 9, 2015A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides The development of a new phosphine ligand…
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