New papers Archives

Long distance call

noviembre 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

Catalytic Mitsunobu: The face-lift of a workhorse

octubre 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

Flowing into indoles

septiembre 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

Review of the Month: Opportunities with Macrocycles

junio 26, 2019

The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.

Re-energizing the Birch reduction

mayo 9, 2019

Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.

(Un)touchable

mayo 25, 2016

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C–F Bond Functionalizations Using a mixed catalytic system to promote the transformation of aromatic fluorides…

Printing Your Catalyst

mayo 6, 2016

3D printing of a heterogeneous copper-based catalyst The impact of some technologies like 3D printing is remarkable. In this case, it…

Activated

enero 25, 2016

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…

More Drugs, Please

enero 21, 2016

One size does not fit all: Challenging some dogmas and taboos in drug discovery This brief review by Chai (Singapore) and…

Monofluorination for You

abril 15, 2015

Monofluorination of Organic Compounds: 10 Years of Innovation This is one review that you must read or you MUST read if…