Papers&Reviews Archives

Easy Access to 2-Aminopyridines

diciembre 4, 2020

This paper describes the development of a novel reagent for the selective amination of pyridines at the C2 position, a work by Fier et al.

A Different Approach to Anilines

noviembre 24, 2020

Earlier this year, Leonori et al. reported a novel and ingenious approach for the synthesis of anilines. Click here to read the full article!

One Way or Another

octubre 29, 2020

Today we talk about this work by Cavallo and Rueping, which describes the regioselective cleavage of epoxides and oxetanes.

The Options Out There

octubre 5, 2020

We feature an article from ACS Med Chem Lett. where seven different C(sp2)–C(sp3) cross-coupling methodologies are compared for highly functionalized substrates.

Standing on the Shoulders of Giants

agosto 5, 2020

Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.

Julia in July

julio 29, 2020

Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.

Lighting up the flow

julio 9, 2020

Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.

Good for your brain and your lab

junio 12, 2020

Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…

Fluorine, pros and cons

mayo 28, 2020

The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?

Three tough atoms

febrero 14, 2020

Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.