New papers

Copper nuggets
Long distance call
noviembre 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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mitsunobo reaction
Catalytic Mitsunobu: The face-lift of a workhorse
octubre 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

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Flowing into indoles
Flowing into indoles
septiembre 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

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Macrocycles
Review of the Month: Opportunities with Macrocycles
junio 26, 2019

The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.

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Birch reduction
Re-energizing the Birch reduction
mayo 9, 2019

Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.

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(Un)touchable
mayo 25, 2016

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C–F Bond Functionalizations Using a mixed catalytic system to promote the transformation of aromatic fluorides…

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Printing Your Catalyst
mayo 6, 2016

3D printing of a heterogeneous copper-based catalyst The impact of some technologies like 3D printing is remarkable. In this case, it…

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Activated
enero 25, 2016

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…

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More Drugs, Please
enero 21, 2016

One size does not fit all: Challenging some dogmas and taboos in drug discovery This brief review by Chai (Singapore) and…

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Monofluorination for You
abril 15, 2015

Monofluorination of Organic Compounds: 10 Years of Innovation This is one review that you must read or you MUST read if…

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