By: Jacobo Cruces

Three tough atoms
Three tough atoms
Febreiro 14, 2020

Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.

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Another long distance call
Xaneiro 13, 2020

Introduction of a CF2H moiety in benzylic positions using a copper catalyst.

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The Less Smelly Way
Decembro 2, 2019

This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Copper nuggets
Long distance call
Novembro 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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mitsunobo reaction
Catalytic Mitsunobu: The face-lift of a workhorse
Outubro 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

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Flowing into indoles
Flowing into indoles
Setembro 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

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Macrocycles
Review of the Month: Opportunities with Macrocycles
Xuño 26, 2019

The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.

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