The Options Out There

Outubro 5, 2020

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We feature an article from ACS Med Chem Lett. where seven different C(sp2)–C(sp3) cross-coupling methodologies are compared for highly functionalized substrates.

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Standing on the shoulders of giants

Agosto 5, 2020

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Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.

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Julia in July

Xullo 29, 2020

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Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.

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Lighting up the flow

Xullo 9, 2020

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Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.

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Good for your brain and your lab

Xuño 12, 2020

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Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…

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Fluorine, pros and cons

Maio 28, 2020

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The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?

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Three tough atoms

Febreiro 14, 2020

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Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.

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Another long distance call

Xaneiro 13, 2020

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Introduction of a CF2H moiety in benzylic positions using a copper catalyst.

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The Less Smelly Way

Decembro 2, 2019

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This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Long distance call

Novembro 6, 2019

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In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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