Standing on the shoulders of giants
Agosto 5, 2020Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.
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Julia in July
Xullo 29, 2020Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.
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Lighting up the flow
Xullo 9, 2020Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.
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Good for your brain and your lab
Xuño 12, 2020Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…
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Fluorine, pros and cons
Maio 28, 2020The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?
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Three tough atoms
Febreiro 14, 2020Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.
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Another long distance call
Xaneiro 13, 2020Introduction of a CF2H moiety in benzylic positions using a copper catalyst.
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The Less Smelly Way
Decembro 2, 2019This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!
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Long distance call
Novembro 6, 2019In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.
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Catalytic Mitsunobu: The face-lift of a workhorse
Outubro 21, 2019This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.
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