Magic methyl nowadays

Abril 9, 2021

---

This review from ChemSocRev by Dixon, Leight et al. covers the different methods currently available for the methylation of sp2 and sp3 C-H positions.

Ler máis

Autocatalytic photoredox Chan–Lam

Marzo 16, 2021

---

This paper by Kozlowski and Jia uses a modern approach: a copper-catalyzed photoredox dehydrogenative Chan–Lam reaction

Ler máis

One-pot access to primary sulfonamides

Febreiro 10, 2021

---

The sulfonamide group is one of those chemical moieties that have been around for a long time, but their preparation is not always trivial.

Ler máis

Easy Access to 2-Aminopyridines

Decembro 4, 2020

---

This paper describes the development of a novel reagent for the selective amination of pyridines at the C2 position, a work by Fier et al.

Ler máis

A Different Approach to Anilines

Novembro 24, 2020

---

Earlier this year, Leonori et al. reported a novel and ingenious approach for the synthesis of anilines. Click here to read the full article!

Ler máis

One Way or Another

Outubro 29, 2020

---

Today we talk about this work by Cavallo and Rueping, which describes the regioselective cleavage of epoxides and oxetanes.

Ler máis

The Options Out There

Outubro 5, 2020

---

We feature an article from ACS Med Chem Lett. where seven different C(sp2)–C(sp3) cross-coupling methodologies are compared for highly functionalized substrates.

Ler máis

Standing on the Shoulders of Giants

Agosto 5, 2020

---

Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.

Ler máis

Julia in July

Xullo 29, 2020

---

Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.

Ler máis

Lighting up the flow

Xullo 9, 2020

---

Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.

Ler máis