New Papers

The Less Smelly Way
Decembro 2, 2019

This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Copper nuggets
Long distance call
Novembro 6, 2019

In this paper, we will see the synthesis of piperidines using a remote d C–H functionalization of amines with a chiral copper catalyst.

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mitsunobo reaction
Catalytic Mitsunobu: The face-lift of a workhorse
Outubro 21, 2019

This work tackles, once again, one of the most used methods to carry out the nucleophilic substitution of alcohols in one step, the Mitsunobu reaction.

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Flowing into indoles
Flowing into indoles
Setembro 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

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Macrocycles
Review of the Month: Opportunities with Macrocycles
Xuño 26, 2019

The macrocycles provides access to new chemical space and opportunities in drug discovery that are otherwise difficult to reach with small molecules.

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Birch reduction
Re-energizing the Birch reduction
Maio 9, 2019

Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.

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Activated
Maio 25, 2016

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…

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Printing Your Catalyst
Maio 6, 2016

3D printing of a heterogeneous copper-based catalyst The impact of some technologies like 3D printing is remarkable. In this case, it…

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(Un)touchable
Xaneiro 25, 2016

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C–F Bond Functionalizations Using a mixed catalytic system to promote the transformation of aromatic fluorides…

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More Drugs, Please
Xaneiro 21, 2016

One size does not fit all: Challenging some dogmas and taboos in drug discovery This brief review by Chai (Singapore) and…

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