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Easy Access to 2-Aminopyridines
Decembro 4, 2020This paper describes the development of a novel reagent for the selective amination of pyridines at the C2 position, a work by Fier et al.
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A Different Approach to Anilines
Novembro 24, 2020Earlier this year, Leonori et al. reported a novel and ingenious approach for the synthesis of anilines. Click here to read the full article!
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One Way or Another
Outubro 29, 2020Today we talk about this work by Cavallo and Rueping, which describes the regioselective cleavage of epoxides and oxetanes.
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The Options Out There
Outubro 5, 2020We feature an article from ACS Med Chem Lett. where seven different C(sp2)–C(sp3) cross-coupling methodologies are compared for highly functionalized substrates.
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Standing on the Shoulders of Giants
Agosto 5, 2020Wei et al. have come up with a new method than can replace aliphatic amino groups with difluoromethyl groups in a rather straightforward manner.
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Julia in July
Xullo 29, 2020Julia is one of the most widely used reactions in organic synthesis. This is a new reagent for the Julia-Kocienski reaction, a modification of the original Julia reaction.
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Lighting up the flow
Xullo 9, 2020Check out our new paper about Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow.
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Good for your brain and your lab
Xuño 12, 2020Diazomethane is a versatile reagent, used for mild methylations, homologations, [3+2] cycloadditions and metal-catalyzed cyclopropanations. Scores high in the atom economy…
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Fluorine, pros and cons
Maio 28, 2020The introduction of fluorine atoms is a widely used approach in medicinal chemistry. It can lead to drugs with improved potency and permeability, but what about its effect on metabolic pathways?
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Three tough atoms
Febreiro 14, 2020Difluoromethylation of Phenols and Thiophenols with S-(Difluoromethyl)sulfonium Salt: Reaction, Scope and Mechanistic Study.
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