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GalChimia conta con proxectos de I+D propios, enfocados á preparación de compostos químicos novos; deste xeito conseguimos aplicar o noso coñecemento químico a campos nos que normalmente non traballamos, como estruturas supramoleculares, nanomateriais e outros.
Publicacións
- Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis. RSC Med. Chem. 2020, DOI: 10.1039/D0MD00203H
- Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound. Tetrahedron Lett. 2019, 60(18), 1243–1248.
- A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J. Med. Chem., 2017, 60 (23), 9575–9584.
- Selective copper-promoted cross-coupling reaction of anilines and alkylboranes, Tetrahedron Lett. 2012, 53(7), 769–772.
- Design of Experiments has far wider use than simply optimising yields, Speciality Chemicals Magazine 2011, 3, 18–19.
- Selective Monomethylation of Anilines by Cu(OAc)2-Promoted Cross-Coupling with MeB(OH)2, Org. Lett. 2009, 11(8), 1677–1680.
- Selective Copper-Promoted Cross-Coupling of Aromatic Amines with Alkyl Boronic Acids, Synlett 2010(14), 2101–2105.
- Microwave-assisted aza-Cope rearrangement of N-allylanilines, Tetrahedron Lett. 2008, 49(12), 2002–2004.
Posters e White Papers
Napropamide impurities and metabolites: a complementary approach using chemical synthesis and biosynthesis
Our collaboration with Hypha Discovery for the preparation of a comprehensive family of napropamide derivatives
Design and Synthesis of linkers for Glycan-Coated Gold Nanoparticles Used in Drug Discovery
Pampín, B.; Codesido, E.; Masse, J.; Cruces, J.
Patentes
- WO 2016078770 (A1) – Preparation of spiro-isoquinoline-1,4′-piperidine compounds having multimodal activity against pain
- WO 2014177517 (A1) – Preparation process of an agonist of the thrombopoietin receptor
- WO 2011147910 (A1) – Pyrazole compounds as sigma receptor inhibitors
- WO 2011051452 (A1) – N-Containing heteroaryl derivates as JAK3 kinase inhibitors
- WO 2009115393 (A1) – Process for the preparation of N-(Phenilethyl) Anilines salts an solvates thereof useful as serotonin 5-HT6 antagonists
- US 7879912 (B2) Process for preparing 3,3-Diarylpropylamines