Boronic Acids

Functionalizing the functionalized
September 1, 2009

Easily Attachable and Detachable ortho-Directing Agent for Arylboronic Acids in Ruthenium-Catalyzed Aromatic C–H Silylation Introduction of diversity in available boronic acids….

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Surprising pivalates
January 1, 2009

Cross-coupling of aryl esters catalyzed by Ni Pivalates are usually considered protecting groups. Change your mind. Transition metal-catalyzed cross-coupling reactions being…

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Racemic resolution
September 1, 2008

Racemic resolution A number of chiral myths exist related to pharmaceutical products. Although nobody here denies the importance of enantioselective synthesis,…

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Skeleton crew
July 1, 2008

A Simple, Modular Synthesis of Substituted Pyridines You have not lived until you have synthesized a highly functionalized pyridine. When the…

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Challenging the C-H
July 1, 2008

In 1995, Barry Trost published his well-known paper on Atom Economy. His concept can be summarized in a few words: stoichiometry…

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Microwave-powered Chan-Lam-Evans
May 1, 2008

Microwave-Assisted Efficient Copper-Promoted N-Arylation of Amines with Arylboronic Acids The Chan–Lam–Evans reaction is a recent addition to the arsenal of the…

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What the Heck
March 1, 2008

Oxygen and Base-Free Oxidative Heck Reactions of Arylboronic Acids with Olefins The Heck reaction has been around for more than 25…

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Buy one, get one free
March 1, 2008

A New Paradigm for Carbon–Carbon Bond Formation: Aerobic, Copper-Templated Cross-Coupling We are used to carry out reactions to yield a product….

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Review of the month: Potassium organotrifluoroborates
March 1, 2008

When organic chemists think about suitable boron groups for cross-coupling, the answer is usually “boronic acids and boronates”. The chemistry for…

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