C-C bond formation

Activated
May 25, 2016

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…

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Tosylates to the Rescue
March 16, 2015

Engaging Nonaromatic, Heterocyclic Tosylates in Reductive Cross-Coupling with Aryl and Heteroaryl Bromides Reductive coupling of common aliphatic heterocycles (piperidines, pyrrolidines, pyranes…

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Sometimes It Happens
March 5, 2015

Nickel-Catalyzed Decarboxylative Cross-Coupling of Perfluorobenzoates with Aryl Halides and Sulfonates Conditions to carry out a Suzuki-like coupling with perfluorinated benzoates. I…

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Drunken Reactions
January 28, 2015

Functionalized olefin cross-coupling to construct carbon-carbon bonds A new method for the generation of quaternary centers using Fe catalysis. Some years…

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You See It, You Don’t
September 1, 2011

Silanol: A Traceless Directing Group for Pd-Catalyzed o-Alkenylation of Phenols C-H activation of phenols using a silanol directing group. Nice paper…

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Surprising pivalates
January 1, 2009

Cross-coupling of aryl esters catalyzed by Ni Pivalates are usually considered protecting groups. Change your mind. Transition metal-catalyzed cross-coupling reactions being…

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Review of the month: Cross Coupling
January 1, 2009

The development of cross-coupling reactions is one of the most innovative fields in Synthetic Organic Chemistry. The advances in recent years…

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No protection required
November 1, 2008

Palladium- and Nickel-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Protons with Organozinc Reagents Zinc can do things that others just…

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Triangles and squares
November 1, 2008

Cross-Coupling of Cyclopropyl- and Cyclobutyltrifluoroborates with Aryl and Heteroaryl Chlorides The introduction of those small funny cycloalkyls is becoming easier. When…

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We are on offer
September 1, 2008

Advances in Carbonylation Carbonylation has changed a lot from its pioneering reactions at high pressure and is becoming an everyday reaction….

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