C-C bond formation

A step forward
September 1, 2008

Pd-Catalyzed Direct Arylation of Tautomerizable Heterocycles with Aryl Boronic Acids via C–OH Bond Activation Using Phosphonium Salts If this method can…

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Review of the month: Coinage metals
September 1, 2008

Coinage metals are probably an intriguing title for most of us. What does that mean? To put it briefly, it refers…

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One step beyond reductive amination
March 1, 2008

Scope of Aminomethylations via Suzuki–Miyaura Cross-Coupling of Organotrifluoroborates Once again, the development of an organometallic cross-coupling reaction increases the array of…

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Buy one, get one free
March 1, 2008

A New Paradigm for Carbon–Carbon Bond Formation: Aerobic, Copper-Templated Cross-Coupling We are used to carry out reactions to yield a product….

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New bases for DoM
January 1, 2008

Direct ortho-Cupration: A New Route to Regioselectively Functionalized Aromatics When talking about directed ortho-metallation (DoM), most people think about organolithium bases,…

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Nitrile synthesis by tandem cyanation/alkylation
January 1, 2008

Convergent Synthesis of Polysubstituted Aromatic Nitriles via Palladium-Catalyzed C–H Functionalization Metal-mediated alkylations and cyanations are not new but, what about accomplishing…

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