Indoles

Flowing into indoles
Flowing into indoles
September 5, 2019

An interesting application of flow chemistry for the continuous synthesis of #indoles through the palladium-catalyzed deoxygenation of nitrostilbenes with CO as the reducing agent.

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Unusual RCM
September 1, 2011

Construction of Carbocyclic Ring of Indoles Using Ruthenium-Catalyzed Ring-Closing Olefin Metathesis Synthesis of highly substituted indoles using a RCM approach. Yoshida…

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CN Without CN
September 1, 2011

Direct Transformation of N,N-Dimethylformamide to -CN: Pd-Catalyzed Cyanation of Heteroarenes via C-H Functionalization Cyanation of protected, C-2 substituted indoles, without using…

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Idoles? No, indoles
May 1, 2009

Rapid and easy access to indoles via microwave-assisted Hemetsberger–Knittel synthesis A straighforward synthesis of indoles using microwave technology. The synthesis of…

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Triple cross
January 1, 2009

Indole Synthesis via Rhodium-Catalyzed Oxidative Coupling of Acetanilides and Internal Alkynes A new preparation of 2,3-disubstituted indoles from o-haloanilines and internal…

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Copper, one way or the other
September 1, 2008

Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles under Mild Conditions In previous issues of this newsletter, we have talked about direct…

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Fishing with Fischer
July 1, 2008

An Expeditious and Environmentally Benign Methodology for the Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones An interesting…

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Room temperature is better
May 1, 2008

Room-Temperature and Phosphine-Free Palladium-Catalyzed Direct C-2 Arylation of Indoles Direct C–H functionalization is an attractive way to increase molecular diversity. A…

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Brevity is the soul of wit
March 1, 2008

Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines Short methods for the preparation of nitrogen heterocycles are always welcome. In this…

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