Patentes y Publicaciones

US 7879912 (B2) Process for preparing 3,3-Diarylpropylamines

WO 2016078770 (A1) – Preparation of spiro-​isoquinoline-​1,​4′-​piperidine compounds having multimodal activity against pain

WO 2014177517 (A1) – Preparation process of an agonist of the thrombopoietin receptor

WO 2011147910 (A1) – Pyrazole compounds as sigma receptor inhibitors

WO 2011051452 (A1) – N-Containing heteroaryl derivates as JAK3 kinase inhibitors

WO 2009115393 (A1) – Process for the preparation of N-(Phenilethyl) Anilines salts an solvates thereof useful as serotonin 5-HT6 antagonists

Structure-guided engineering of a receptor-agonist pair for inducible activation of the ABA adaptive response to drought. Sci.Adv. 2023, 9, ade9948.

Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity” J. Med. Chem. 2022, 65, 7, 5449–5461.

EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J. Med. Chem. 2020, 63, 23, 14979–14988.

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis. RSC Med. Chem. 2020,11, 1168–1177.

Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound. Tetrahedron Lett. 2019, 60(18), 1243–1248.

Adsorption of Pharmaceutical Pollutants from Water Using Covalent Organic Frameworks. Chem. Eur. J. 2018, 24(42), 10601-10605.

A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J. Med. Chem., 2017, 60 (23), 9575–9584.

Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 2: Introduction of cyclic substituents in position 4. Med. Chem. Commun. 2017, 8, 1246–1254.

Right by design. Editorial in Speciality Chemicals Magazine 2011, 3, 18–19.

Selective copper-promoted cross-coupling reaction of anilines and alkylboranes, Tetrahedron Lett. 2012, 53(7), 769–772.

Selective Monomethylation of Anilines by Cu(OAc)2-Promoted Cross-Coupling with MeB(OH)2, Org. Lett. 2009, 11(8), 1677–1680.

Selective Copper-Promoted Cross-Coupling of Aromatic Amines with Alkyl Boronic Acids, Synlett 2010(14), 2101–2105.

Microwave-assisted aza-Cope rearrangement of N-allylanilines, Tetrahedron Lett. 2008, 49(12), 2002–2004.