Custom Synthesis business line is intended to provide clients with scaffolds, building blocks, pharmacological standards, reference standards, metabolites, impurities, etc., that are not commercially available.


aims

AIMS

· 50 g of a competitor’s standard required by mid-size pharma for in vivo assays.

· Patented route for the product described a 0.2% yield in 6 steps.

 

actions

ACTIONS

· Several alternatives developed for the synthesis of the required fragments.

· Dozens of reaction conditions tried for each critical step.

· Exploration of different approaches suitable for scale-up.

 

achievments

ACHIEVEMENTS

· Three new synthesis routes developed.

· Preferred new route delivered grams in 6 steps with 61% yield using cheaper materials.

· New routes patented to block competitor’s IP.