baran

The state of organic synthesis

Marzo 4, 2020

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Gaich et al. have recently reported the total synthesis of an extremely complicated molecule, canataxpropellane. We thus wonder, have we reached the limits of synthetic complexity?

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Re-energizing the Birch reduction

Maio 9, 2019

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Phil S. Baran and his co-workers had made a reality above chemical dreams by the application of Li-ion battery chemistry in synthetic organic electroreduction.

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Activated

Maio 25, 2016

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A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Activated esters of alkylic acids as building blocks for the…

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Impressive, Most Impressive

Maio 27, 2015

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Practical olefin hydroamination with nitroarenes A new, powerful method to generate quaternary amines without using expensive catalysts. Baran has done it…

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A New Age for Chlorination

Febreiro 20, 2015

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A Practical Lewis Base Catalyzed Electrophilic Chlorination of Arenes and Heterocycles Mild chlorination method of arenes and heteroarenes. Here you have…

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Drunken Reactions

Xaneiro 28, 2015

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Functionalized olefin cross-coupling to construct carbon-carbon bonds A new method for the generation of quaternary centers using Fe catalysis. Some years…

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Methylation Made Simpler

Decembro 9, 2014

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C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase A commercial reagent that you can use to introduce methyl groups…

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Radical Indeed

Outubro 1, 2011

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Practical Radical Cyclizations with Arylboronic Acids and Trifluoroborates A practical radical cyclization using boronic acids and trifluoroborates. Hmmm, this came like…

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Heterocyclic CF3

Outubro 1, 2011

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Innate C-H trifluoromethylation of heterocycles Introduction of the trifluoromethyl moiety into heterocycles. I admit that I almost missed this paper. Honestly,…

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