Multicomponent reactions (MCRs) are chemical transformations in which three or more reactants form a product derived from all of the inputs. These type of reactions introduce the most of diversity in one step, making full use of the many building blocks available today from commercial vendors. The interest in MCRs has boosted during the past two decades since are a very useful tool for the efficient synthesis of small molecule libraries. The review “Recent advances in multicomponent reactions for diversity-oriented synthesis” by Shaw et al. covers recent advances in the area of MCR chemistry, including new reactions, asymmetric catalysts, synthesis of natural products libraries and others.
Recent advances in multicomponent reactions for diversity-oriented synthesis
Curr. Op. Chem. Biol. 2010, 14(3) (8), pp 371-382.