Trifluoromethylation

The Less Smelly Way
December 2, 2019

This paper came to our attention thanks to one of our Project Managers, always watching for new useful reactions. Check it out now!

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Mixing is Right
March 9, 2015

Condensed-Phase, Halogen-Bonded CF3I and C2F5I Adducts for Perfluoroalkylation Reactions An old reagent for trifluoromethylation turned user-friendly. It is a pity that…

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Review of the month: Fluorination Methods
February 16, 2015

It is curious how these things happen. These last weeks I have been checking old entries of the blog, and I…

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New Section?
December 1, 2011

Synthesis of 2-(Trifluoromethyl)oxazoles from ß-Monosubstituted Enamines via PhI(OCOCF3)2-Mediated Trifluoroacetoxylation and Cyclization Synthesis of trifluoromethylated oxazoles from enamines and PIFA. If this…

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What you Missed Last Month
December 1, 2011

What can we say? CPhI is really important and we had some very important activities going on, such as preparing the…

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And More CF3
October 1, 2011

Silver-Mediated Trifluoromethylation of Arenes Using TMSCF3 Introduction of the trifluoromethyl moiety into aromatic rings. And now by Sanford et al. (University…

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Allylic CF3
October 1, 2011

Copper-Catalyzed C(sp3)–C(sp3) Bond Formation Using a Hypervalent Iodine Reagent: An Efficient Allylic Trifluoromethylation Introduction of the trifluoromethyl moiety in allylic positions….

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Heterocyclic CF3
October 1, 2011

Innate C-H trifluoromethylation of heterocycles Introduction of the trifluoromethyl moiety into heterocycles. I admit that I almost missed this paper. Honestly,…

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The Smelly Way
April 1, 2010

From Carboxylic Acids to the Trifluoromethyl Group Using BrF3 A method to convert carboxylic acids into trifluoromethyl groups. This paper by…

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